Publications

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2016


  1. Stanley, N. Pardo, L. Fabritiis, GD.
    “The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor.”
    Sci Rep 6(0) 22639–
    Abstract PubMed Link

  2. Doornbos, ML. Perez-Benito, L. Tresadern, G. Mulder-Krieger, T. Biesmans, I. Trabanco, AA. Cid, JM. Lavreysen, H. IJzerman, AP. Heitman, LH.
    “Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.”
    Br J Pharmacol 173(3) 588–600
    Abstract PubMed Link

  3. Srinivasan, S. Cordomi, A. Ramon, E. Garriga, P.
    “Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration.”
    Cell Mol Life Sci 73(6) 1253–63
    Abstract PubMed Link

  4. Navarro, G. Cordomi, A. Zelman-Femiak, M. Brugarolas, M. Moreno, E. Aguinaga, D. Perez-Benito, L. Cortes, A. Casado, V. Mallol, J. Canela, EI. Lluis, C. Pardo, L. Garcia-Saez, AJ. McCormick, PJ. Franco, R.
    “Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.”
    BMC Biol 14(1) 26–
    Abstract PubMed Link

  5. Gomez-Tamayo, JC. Cordomi, A. Olivella, M. Mayol, E. Fourmy, D. Pardo, L.
    “Analysis of the interactions of sulfur-containing amino acids in membrane proteins.”
    Protein Sci 25(8) 1517–24
    Abstract PubMed Link

  6. Cid, JM. Tresadern, G. Vega, JA. de, Lucas, AI. Del, Cerro, A. Matesanz, E. Linares, ML. Garcia, A. Iturrino, L. Perez-Benito, L. Macdonald, GJ. Oehlrich, D. Lavreysen, H. Peeters, L. Ceusters, M. Ahnaou, A. Drinkenburg, W.
    “Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)me thyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).”
    J Med Chem 59(18) 8495–507
    Abstract PubMed Link

  7. Ciordia, M. Perez-Benito, L. Delgado, F. Trabanco, AA. Tresadern, G.
    “Application of Free Energy Perturbation for the Design of BACE1 Inhibitors.”
    J Chem Inf Model 56(9) 1856–71
    Abstract PubMed Link

  8. Cordomi, A. Fourmy, D. Tikhonova, IG.
    “Gut hormone GPCRs: structure, function, drug discovery.”
    Curr Opin Pharmacol 31(0) 63–67
    Abstract PubMed Link