Publications

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2017


  1. Gonzalez-Vera, JA. Medina, RA. Martin-Fontecha, M. Gonzalez, A. de, la, Fuente, T. Vazquez-Villa, H. Garcia-Carceles, J. Botta, J. McCormick, PJ. Benhamu, B. Pardo, L. Lopez-Rodriguez, ML.
    “A new serotonin 5-HT6 receptor antagonist with procognitive activity – Importance of a halogen bond interaction to stabilize the binding.”
    Sci Rep 7(0) 41293–
    Abstract PubMed Link

  2. Marin-Ramos, NI. Pinar, C. Vazquez-Villa, H. Martin-Fontecha, M. Gonzalez, A. Canales, A. Algar, S. Mayo, PP. Jimenez-Barbero, J. Gajate, C. Mollinedo, F. Pardo, L. Ortega-Gutierrez, S. Viso, A. Lopez-Rodriguez, ML.
    “Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.”
    Chemistry 23(7) 1676–1685
    Abstract PubMed Link

2016


  1. Stanley, N. Pardo, L. Fabritiis, GD.
    “The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor.”
    Sci Rep 6(0) 22639–
    Abstract PubMed Link

  2. Doornbos, ML. Perez-Benito, L. Tresadern, G. Mulder-Krieger, T. Biesmans, I. Trabanco, AA. Cid, JM. Lavreysen, H. IJzerman, AP. Heitman, LH.
    “Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.”
    Br J Pharmacol 173(3) 588–600
    Abstract PubMed Link

  3. Srinivasan, S. Cordomi, A. Ramon, E. Garriga, P.
    “Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration.”
    Cell Mol Life Sci 73(6) 1253–63
    Abstract PubMed Link

  4. Navarro, G. Cordomi, A. Zelman-Femiak, M. Brugarolas, M. Moreno, E. Aguinaga, D. Perez-Benito, L. Cortes, A. Casado, V. Mallol, J. Canela, EI. Lluis, C. Pardo, L. Garcia-Saez, AJ. McCormick, PJ. Franco, R.
    “Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.”
    BMC Biol 14(1) 26–
    Abstract PubMed Link

  5. Gomez-Tamayo, JC. Cordomi, A. Olivella, M. Mayol, E. Fourmy, D. Pardo, L.
    “Analysis of the interactions of sulfur-containing amino acids in membrane proteins.”
    Protein Sci 25(8) 1517–24
    Abstract PubMed Link

  6. Cid, JM. Tresadern, G. Vega, JA. de, Lucas, AI. Del, Cerro, A. Matesanz, E. Linares, ML. Garcia, A. Iturrino, L. Perez-Benito, L. Macdonald, GJ. Oehlrich, D. Lavreysen, H. Peeters, L. Ceusters, M. Ahnaou, A. Drinkenburg, W.
    “Discovery of 8-Trifluoromethyl-3-cyclopropylmethyl-7-[(4-(2,4-difluorophenyl)-1-piperazinyl)me thyl]-1,2,4-triazolo[4,3-a]pyridine (JNJ-46356479), a Selective and Orally Bioavailable mGlu2 Receptor Positive Allosteric Modulator (PAM).”
    J Med Chem 59(18) 8495–507
    Abstract PubMed Link

  7. Ciordia, M. Perez-Benito, L. Delgado, F. Trabanco, AA. Tresadern, G.
    “Application of Free Energy Perturbation for the Design of BACE1 Inhibitors.”
    J Chem Inf Model 56(9) 1856–71
    Abstract PubMed Link

  8. Cordomi, A. Fourmy, D. Tikhonova, IG.
    “Gut hormone GPCRs: structure, function, drug discovery.”
    Curr Opin Pharmacol 31(0) 63–67
    Abstract PubMed Link

2015


  1. Sposini, S. Caltabiano, G. Hanyaloglu, AC. Miele, R.
    “Identification of transmembrane domains that regulate spatial arrangements and activity of prokineticin receptor 2 dimers.”
    Mol Cell Endocrinol 399(0) 362–72
    Abstract PubMed Link

  2. Vinals, X. Moreno, E. Lanfumey, L. Cordomi, A. Pastor, A. de, La, Torre, R. Gasperini, P. Navarro, G. Howell, LA. Pardo, L. Lluis, C. Canela, EI. McCormick, PJ. Maldonado, R. Robledo, P.
    “Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.”
    PLoS Biol 13(7) e10021–
    Abstract PubMed Link

  3. Rios, S. Fernandez, MF. Caltabiano, G. Campillo, M. Pardo, L. Gonzalez, A.
    “GPCRtm: An amino acid substitution matrix for the transmembrane region of class A G Protein-Coupled Receptors.”
    BMC Bioinformatics 16(0) 206–
    Abstract PubMed Link

  4. Matsoukas, MT. Aranguren-Ibanez, A. Lozano, T. Nunes, V. Lasarte, JJ. Pardo, L. Perez-Riba, M.
    “Identification of small-molecule inhibitors of calcineurin-NFATc signaling that mimic the PxIxIT motif of calcineurin binding partners.”
    Sci Signal 8(382) ra63–
    Abstract PubMed Link

  5. Cordomi, A. Ismail, S. Matsoukas, MT. Escrieut, C. Gherardi, MJ. Pardo, L. Fourmy, D.
    “Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors.”
    Biochem Pharmacol 96(3) 237–46
    Abstract PubMed Link

  6. Molero, A. Vendrell, M. Bonaventura, J. Zachmann, J. Lopez, L. Pardo, L. Lluis, C. Cortes, A. Albericio, F. Casado, V. Royo, M.
    “A solid-phase combinatorial approach for indoloquinolizidine-peptides with high affinity at D1 and D2 dopamine receptors.”
    Eur J Med Chem 97(0) 173–80
    Abstract PubMed Link

  7. Masia-Balague, M. Izquierdo, I. Garrido, G. Cordomi, A. Perez-Benito, L. Miller, NL. Schlaepfer, DD. Gigoux, V. Aragay, AM.
    “Gastrin-stimulated Galpha13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells.”
    J Biol Chem 290(24) 15197–209
    Abstract PubMed Link

  8. Marsango, S. Caltabiano, G. Pou, C. Varela, Liste, MJ. Milligan, G.
    “Analysis of Human Dopamine D3 Receptor Quaternary Structure.”
    J Biol Chem 290(24) 15146–62
    Abstract PubMed Link

  9. Liste, MJ. Caltabiano, G. Ward, RJ. Alvarez-Curto, E. Marsango, S. Milligan, G.
    “The molecular basis of oligomeric organization of the human M3 muscarinic acetylcholine receptor.”
    Mol Pharmacol 87(6) 936–53
    Abstract PubMed Link

  10. Cordomi, A. Navarro, G. Aymerich, MS. Franco, R.
    “Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins.”
    Trends Biochem Sci 40(10) 548–51
    Abstract PubMed Link

  11. Perea, M. Lugtenburg, I. Mayol, E. Cordomi, A. Deupi, X. Pardo, L. Olivella, M.
    “TMalphaDB and TMbetaDB: web servers to study the structural role of sequence motifs in alpha-helix and beta-barrel domains of membrane proteins.”
    BMC Bioinformatics 16(0) 266–
    Abstract PubMed Link

  12. Rosa, M. Caltabiano, G. Barreto-Valer, K. Gonzalez-Nunez, V. Gomez-Tamayo, JC. Arda, A. Jimenez-Barbero, J. Pardo, L. Rodriguez, RE. Arsequell, G. Valencia, G.
    “Modulation of the Interaction between a Peptide Ligand and a G Protein-Coupled Receptor by Halogen Atoms.”
    ACS Med Chem Lett 6(8) 872–6
    Abstract PubMed Link

  13. Simeon-Aznar, CP. Fonollosa-Pla, V. Tolosa-Vilella, C. Espinosa-Garriga, G. Campillo-Grau, M. Ramos-Casals, M. Garcia-Hernandez, FJ. Castillo-Palma, MJ. Sanchez-Roman, J. Callejas-Rubio, JL. Ortego-Centeno, N. Egurbide-Arberas, MV.
    “Registry of the Spanish Network for Systemic Sclerosis: Survival, Prognostic Factors, and Causes of Death.”
    Medicine (Baltimore) 94(43) e1728–
    Abstract PubMed Link

2014


  1. He, HQ. Troksa, EL. Caltabiano, G. Pardo, L. Ye, RD.
    “Structural determinants for the interaction of formyl Peptide receptor 2 with Peptide ligands.”
    J Biol Chem 289(4) 2295–306
    Abstract PDF PubMed Link

  2. Ramos, L. Del, Rey, J. Daina, G. Martinez-Passarell, O. Rius, M. Tunon, D. Campillo, M. Benet, J. Navarro, J.
    “Does the S phase have an impact on the accuracy of comparative genomic hybridization profiles in single fibroblasts and human blastomeres?”
    Fertil Steril 101(2) 488–495.e3
    Abstract PDF PubMed Link

  3. Gonzalez, A. Cordomi, A. Matsoukas, M. Zachmann, J. Pardo, L.
    “Modeling of g protein-coupled receptors using crystal structures: from monomers to signaling complexes.”
    Adv Exp Med Biol 796(0) 15–33
    Abstract PDF PubMed Link

  4. Daina, G. Ramos, L. Rius, M. Obradors, A. Del, Rey, J. Giralt, M. Campillo, M. Velilla, E. Pujol, A. Martinez-Pasarell, O. Benet, J. Navarro, J.
    “Non-meiotic chromosome instability in human immature oocytes.”
    Eur J Hum Genet 22(2) 202–7
    Abstract PubMed Link

  5. Medina, RA. Vazquez-Villa, H. Gomez-Tamayo, JC. Benhamu, B. Martin-Fontecha, M. de, la, Fuente, T. Caltabiano, G. Hedlund, PB. Pardo, L. Lopez-Rodriguez, ML.
    “The Extracellular Entrance Provides Selectivity to Serotonin 5-HT7 Receptor Antagonists with Antidepressant-like Behavior in Vivo.”
    J Med Chem 57(15) 6879–84
    Abstract PDF PubMed Link

  6. Spyridaki, K. Matsoukas, MT. Cordomi, A. Gkountelias, K. Papadokostaki, M. Mavromoustakos, T. Logothetis, DE. Margioris, AN. Pardo, L. Liapakis, G.
    “Structural-Functional Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1 Receptor: ROLE IN ACTIVATION AND ALLOSTERIC ANTAGONISM.”
    J Biol Chem 289(27) 18966–77
    Abstract PDF PubMed Link

  7. Kekarainen, T. Gonzalez, A. Llorens, A. Segales, J.
    “Genetic variability of porcine circovirus 2 in vaccinating and non-vaccinating commercial farms.”
    J Gen Virol 95(0) 1734–42
    Abstract PubMed Link

  8. Srinivasan, S. Ramon, E. Cordomi, A. Garriga, P.
    “Binding specificity of retinal analogs to photoactivated visual pigments suggest mechanism for fine-tuning GPCR-ligand interactions.”
    Chem Biol 21(3) 369–78
    Abstract PDF PubMed Link

  9. MacKenzie, AE. Caltabiano, G. Kent, TC. Jenkins, L. McCallum, JE. Hudson, BD. Nicklin, SA. Fawcett, L. Markwick, R. Charlton, SJ. Milligan, G.
    “The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35.”
    Mol Pharmacol 85(1) 91–104
    Abstract PDF PubMed Link

  10. Benhamu, B. Martin-Fontecha, M. Vazquez-Villa, H. Pardo, L. Lopez-Rodriguez, ML.
    “Serotonin 5-HT6 Receptor Antagonists for the Treatment of Cognitive Deficiency in Alzheimer\’s Disease.”
    J Med Chem 57(17) 7160–81
    Abstract PDF PubMed Link

  11. Fortuna, CG. Berardozzi, R. Bonaccorso, C. Caltabiano, G. Di, Bari, L. Goracci, L. Guarcello, A. Pace, A. Palumbo, Piccionello, A. Pescitelli, G. Pierro, P. Lonati, E. Bulbarelli, A. Cocuzza, CE. Musumarra, G. Musumeci, R.
    “New potent antibacterials against Gram-positive multiresistant pathogens: Effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles.”
    Bioorg Med Chem 22(24) 6814–25
    Abstract PubMed Link

  12. Ramon, E. Cordomi, A. Aguila, M. Srinivasan, S. Dong, X. Moore, AT. Webster, AR. Cheetham, ME. Garriga, P.
    “Differential Light-induced Responses in Sectorial Inherited Retinal Degeneration.”
    J Biol Chem 289(52) 35918–28
    Abstract PubMed Link

  13. Simeon-Aznar, CP. Tolosa-Vilella, C. Gabarro-Julia, L. Campillo-Grau, M. Guillen, Del, Castillo, A. Fonollosa-Pla, V. Vilardell-Tarres, M.
    “Systemic sclerosis sine scleroderma and limited cutaneous systemic sclerosis: similarities and differences.”
    Clin Exp Rheumatol 32(6) S–33
    Abstract PubMed Link

2013


  1. Caltabiano, G. Gonzalez, A. Cordomi, A. Campillo, M. Pardo, L.
    “The role of hydrophobic amino acids in the structure and function of the rhodopsin family of g protein-coupled receptors.”
    Methods Enzymol 520(0) 99–115
    Abstract PDF PubMed Link

  2. Gandia, J. Fernandez-Duenas, V. Morato, X. Caltabiano, G. Gonzalez-Muniz, R. Pardo, L. Stagljar, I. Ciruela, F.
    “The Parkinson\’s disease-associated GPR37 receptor-mediated cytotoxicity is controlled by its intracellular cysteine-rich domain.”
    J Neurochem 125(3) 362–72
    Abstract PDF PubMed Link

  3. Olivella, M. Gonzalez, A. Pardo, L. Deupi, X.
    “Relation between sequence and structure in membrane proteins.”
    Bioinformatics 29(13) 1589–92
    Abstract PDF PubMed Link

  4. Cordomi, A. Gomez-Tamayo, JC. Gigoux, V. Fourmy, D.
    “Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function.”
    Trends Pharmacol Sci 34(6) 320–31
    Abstract PDF PubMed Link

  5. Fortuna, CG. Bonaccorso, C. Bulbarelli, A. Caltabiano, G. Rizzi, L. Goracci, L. Musumarra, G. Pace, A. Palumbo, Piccionello, A. Guarcello, A. Pierro, P. Cocuzza, CE. Musumeci, R.
    “New linezolid-like 1,2,4-oxadiazoles active against Gram-positive multiresistant pathogens.”
    Eur J Med Chem 65(0) 533–45
    Abstract PDF PubMed Link

  6. Olivella, M. Caltabiano, G. Cordomi, A.
    “The role of Cysteine 6.47 in class A GPCRs.”
    BMC Struct Biol 13(0) 3–
    Abstract PDF PubMed Link

  7. Matsoukas, MT. Cordomi, A. Rios, S. Pardo, L. Tselios, T.
    “Ligand Binding Determinants for Angiotensin II Type 1 Receptor from Computer Simulations.”
    J Chem Inf Model 53(11) 2874–83
    Abstract PDF PubMed Link

  8. Matsoukas, MT. Potamitis, C. Plotas, P. Androutsou, ME. Agelis, G. Matsoukas, J. Zoumpoulakis, P.
    “Insights into AT1 Receptor Activation through AngII Binding Studies.”
    J Chem Inf Model 53(11) 2798–811
    Abstract PDF PubMed Link

2012


  1. Liapakis, G. Cordomi, A. Pardo, L.
    “The G-protein Coupled Receptor Family: Actors with Many Faces.”
    Curr Pharm Des 18(2) 175–85
    Abstract PDF PubMed Link

  2. Cordomi, A. Caltabiano, G. Pardo, L.
    “Membrane Protein Simulations Using AMBER Force Field and Berger Lipid Parameters”
    J Chem Theory Comput 8(3) 948–958
    Abstract PDF

  3. Manglik, A. Kruse, AC. Kobilka, TS. Thian, FS. Mathiesen, JM. Sunahara, RK. Pardo, L. Weis, WI. Kobilka, BK. Granier, S.
    “Crystal structure of the micro-opioid receptor bound to a morphinan antagonist.”
    Nature 485(7398) 321–6
    Abstract PDF PubMed Link

  4. Gonzalez, A. Cordomi, A. Caltabiano, G. Pardo, L.
    “Impact of helix irregularities on sequence alignment and homology modeling of g protein-coupled receptors.”
    Chembiochem 13(10) 1393–9
    Abstract PDF PubMed Link

  5. Ersoy, BA. Pardo, L. Zhang, S. Thompson, DA. Millhauser, G. Govaerts, C. Vaisse, C.
    “Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR.”
    Nat Chem Biol 8(8) 725–730
    Abstract PDF PubMed Link

  6. Martin-Couce, L. Martin-Fontecha, M. Palomares, O. Mestre, L. Cordomi, A. Hernangomez, M. Palma, S. Pardo, L. Guaza, C. Lopez-Rodriguez, ML. Ortega-Gutierrez, S.
    “Chemical probes for the recognition of cannabinoid receptors in native systems.”
    Angew Chem Int Ed Engl 51(28) 6896–9
    Abstract PDF PubMed Link

  7. Blattermann, S. Peters, L. Ottersbach, PA. Bock, A. Konya, V. Weaver, CD. Gonzalez, A. Schroder, R. Tyagi, R. Luschnig, P. Gab, J. Hennen, S. Ulven, T. Pardo, L. Mohr, K. Gutschow, M. Heinemann, A. Kostenis, E.
    “A biased ligand for OXE-R uncouples Galpha and Gbetagamma signaling within a heterotrimer.”
    Nat Chem Biol 8(7) 631–638
    Abstract PDF PubMed Link

  8. Simeon-Aznar, CP. Fonollosa-Pla, V. Tolosa-Vilella, C. Espinosa-Garriga, G. Ramos-Casals, M. Campillo-Grau, M. Garcia-Hernandez, FJ. Castillo-Palma, MJ. Sanchez-Roman, J. Callejas-Rubio, JL. Ortego-Centeno, N. Egurbide-Arberas, MV.
    “Registry of the Spanish network for systemic sclerosis: clinical pattern according to cutaneous subsets and immunological status.”
    Semin Arthritis Rheum 41(6) 789–800
    Abstract PubMed Link

2011


  1. Sansuk, K. Deupi, X. Torrecillas, IR. Jongejan, A. Nijmeijer, S. Bakker, RA. Pardo, L. Leurs, R.
    “A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation.”
    Mol Pharmacol 79(2) 262–9
    Abstract PDF PubMed Link

  2. Orcajo-Rincon, AL. Ortega-Gutierrez, S. Serrano, P. Torrecillas, IR. Wuthrich, K. Campillo, M. Pardo, L. Viso, A. Benhamu, B. Lopez-Rodriguez, ML.
    “Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy.”
    J Med Chem 54(4) 1096–1100
    Abstract PDF PubMed Link

  3. Bosch-Presegue, L. Iarriccio, L. Aguila, M. Toledo, D. Ramon, E. Cordomi, A. Garriga, P.
    “Hydrophobic amino acids at the cytoplasmic ends of helices 3 and 6 of rhodopsin conjointly modulate transducin activation.”
    Arch Biochem Biophys 506(2) 142–9
    Abstract PDF PubMed Link

  4. Gonzalez, A. Murcia, M. Benhamu, B. Campillo, M. Lopez-Rodriguez, ML. Pardo, L.
    “The importance of solvation in the design of ligands targeting membrane proteins”
    Med Chem Commun 2(3) 160–164
    Abstract PDF

  5. Sriphrapradang, C. Tenenbaum-Rakover, Y. Weiss, M. Barkoff, MS. Admoni, O. Kawthar, D. Caltabiano, G. Pardo, L. Dumitrescu, AM. Refetoff, S.
    “The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlation.”
    J Clin Endocrinol Metab 96(6) e1001–e1006
    Abstract PubMed Link

  6. Bosch-Presegue, L. Ramon, E. Toledo, D. Cordomi, A. Garriga, P.
    “Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa.”
    FEBS J 278(9) 1493–1505
    Abstract PDF PubMed Link

  7. Perez-Victoria, JM. Bavchvarov, BI. Torrecillas, IR. Martinez-Garcia, M. Lopez-Martin, C. Campillo, M. Castanys, S. Gamarro, F.
    “Sitamaquine overcomes ABC-mediated resistance to miltefosine and antimony in Leishmania.”
    Antimicrob Agents Chemother 55(8) 3838–44
    Abstract PDF PubMed Link

  8. Solans-Laque, R. Lopez-Hernandez, A. Angel, Bosch-Gil, J. Palacios, A. Campillo, M. Vilardell-Tarres, M.
    “Risk, Predictors, and Clinical Characteristics of Lymphoma Development in Primary Sjogren\’s Syndrome.”
    Semin Arthritis Rheum 41(3) 415–23
    Abstract PDF PubMed Link

  9. Gonzalez, A. Perez-Acle, T. Pardo, L. Deupi, X.
    “Molecular Basis of Ligand Dissociation in beta-Adrenergic Receptors.”
    PLoS One 6(9) e23815–
    Abstract PDF PubMed Link

  10. Christiansen, E. Urban, C. Grundmann, M. Due-Hansen, ME. Hagesaether, E. Schmidt, J. Pardo, L. Ullrich, S. Kostenis, E. Kassack, M. Ulven, T.
    “Identification of a Potent and Selective Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist with Favorable Physicochemical and in Vitro ADME Properties.”
    J Med Chem 54(19) 6691–703
    Abstract PDF PubMed Link

  11. Toledo, D. Ramon, E. Aguila, M. Cordomi, A. Perez, JJ. Mendes, HF. Cheetham, ME. Garriga, P.
    “Molecular mechanisms of disease for mutations at gly-90 in rhodopsin.”
    J Biol Chem 286(46) 39993–40001
    Abstract PDF PubMed Link

  12. Marco, I. Valhondo, M. Martin-Fontecha, M. Vazquez-Villa, H. Del, Rio, J. Planas, A. Sagredo, O. Ramos, JA. Torrecillas, IR. Pardo, L. Frechilla, D. Benhamu, B. Lopez-Rodriguez, ML.
    “New Serotonin 5-HT(1A) Receptor Agonists with Neuroprotective Effect against Ischemic Cell Damage.”
    J Med Chem 54(23) 7986–7999
    Abstract PDF PubMed Link

2010


  1. Deupi, X. Olivella, M. Sanz, A. Dolker, N. Campillo, M. Pardo, L.
    “Influence of the g- conformation of Ser and Thr on the structure of transmembrane helices.”
    J Struct Biol 169(1) 116–123
    Abstract PDF PubMed Link

  2. Bokoch, MP. Zou, Y. Rasmussen, SG. Liu, CW. Nygaard, R. Rosenbaum, DM. Fung, JJ. Choi, HJ. Thian, FS. Kobilka, TS. Puglisi, JD. Weis, WI. Pardo, L. Prosser, RS. Mueller, L. Kobilka, BK.
    “Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.”
    Nature 463(7277) 108–12
    Abstract PDF PubMed Link

  3. de, la, Fuente, T. Martin-Fontecha, M. Sallander, J. Benhamu, B. Campillo, M. Medina, RA. Pellissier, LP. Claeysen, S. Dumuis, A. Pardo, L. Lopez-Rodriguez, ML.
    “Benzimidazole Derivatives as New Serotonin 5-HT(6) Receptor Antagonists. Molecular Mechanisms of Receptor Inactivation.”
    J Med Chem 53(3) 1357–1369
    Abstract PDF PubMed Link

  4. Prat, E. Del, Rey, J. Ponsa, I. Nadal, M. Camps, J. Plaja, A. Campillo, M. Algaba, F. Gelabert, A. Miro, R.
    “Comparative Genomic Hybridization Analysis Reveals New Different Subgroups in Early-stage Bladder Tumors.”
    Urology 75(2) 347–355
    Abstract PDF PubMed Link

  5. Ye, S. Zaitseva, E. Caltabiano, G. Schertler, GF. Sakmar, TP. Deupi, X. Vogel, R.
    “Tracking G-protein-coupled receptor activation using genetically encoded infrared probes.”
    Nature 464(7293) 1386–9
    Abstract PubMed Link

  6. Perez-Bocanegra, C. Solans-Laque, R. Simeon-Aznar, CP. Campillo, M. Fonollosa-Pla, V. Vilardell-Tarres, M.
    “Age-related survival and clinical features in systemic sclerosis patients older or younger than 65 at diagnosis.”
    Rheumatology (Oxford) 49(6) 1112–7
    Abstract PDF PubMed Link

  7. Navarro, G. Ferre, S. Cordomi, A. Moreno, E. Mallol, J. Casado, V. Cortes, A. Hoffmann, H. Ortiz, J. Canela, EI. Lluis, C. Pardo, L. Franco, R. Woods, AS.
    “Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers.”
    J Biol Chem 285(35) 27346–59
    Abstract PDF PubMed Link

  8. Deupi, X. Kobilka, BK.
    “Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function.”
    Physiology (Bethesda) 25(5) 293–303
    Abstract PubMed Link

2009


  1. Schroder, R. Merten, N. Mathiesen, JM. Martini, L. Kruljac-Letunic, A. Krop, F. Blaukat, A. Fang, Y. Tran, E. Ulven, T. Drewke, C. Whistler, J. Pardo, L. Gomeza, J. Kostenis, E.
    “The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains G{alpha}i and Downstream Signaling Cascade Activation.”
    J Biol Chem 284(2) 1324–36
    Abstract PDF PubMed Link

  2. Pellissier, LP. Sallander, J. Campillo, M. Gaven, F. Queffeulou, E. Pillot, M. Dumuis, A. Claeysen, S. Bockaert, J. Pardo, L.
    “Conformational toggle switches implicated in basal constitutive and agonist-induced activated states of 5-hydroxytryptamine-4 receptors.”
    Mol Pharmacol 75(4) 982–90
    Abstract PDF PubMed Link

  3. Medina, RA. Sallander, J. Benhamu, B. Porras, E. Campillo, M. Pardo, L. Lopez-Rodriguez, ML.
    “Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.”
    J Med Chem 52(8) 2384–92
    Abstract PDF PubMed Link

  4. Fung, JJ. Deupi, X. Pardo, L. Yao, XJ. Velez-Ruiz, GA. Devree, BT. Sunahara, RK. Kobilka, BK.
    “Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer.”
    EMBO J 28(21) 3315–3328
    Abstract PDF PubMed Link

  5. Yao, XJ. Velez, Ruiz, G. Whorton, MR. Rasmussen, SG. DeVree, BT. Deupi, X. Sunahara, RK. Kobilka, B.
    “The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex.”
    Proc Natl Acad Sci U S A 106(23) 9501–6
    Abstract PDF PubMed Link

2008


  1. De, Leener, A. Caltabiano, G. Erkan, S. Idil, M. Vassart, G. Pardo, L. Costagliola, S.
    “Identification of the first germline mutation in the extracellular domain of the follitropin receptor responsible for spontaneous ovarian hyperstimulation syndrome.”
    Hum Mutat 29(1) 91–98
    Abstract PDF PubMed Link

  2. Bakker, RA. Jongejan, A. Sansuk, K. Hacksell, U. Timmerman, H. Brann, MR. Weiner, DM. Pardo, L. Leurs, R.
    “Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors.”
    Mol Pharmacol 73(1) 94–103
    Abstract PDF PubMed Link

  3. Caltabiano, G. Campillo, M. De, Leener, A. Smits, G. Vassart, G. Costagliola, S. Pardo, L.
    “The specificity of binding of glycoprotein hormones to their receptors.”
    Cell Mol Life Sci 65(16) 2484–92
    Abstract PDF PubMed Link

  4. Royer, J. Lefevre-Minisini, A. Caltabiano, G. Lacombe, T. Malthiery, Y. Savagner, F. Pardo, L. Rodien, P.
    “The cloned equine thyrotropin receptor is hypersensitive to human chorionic gonadotropin; identification of three residues in the extracellular domain involved in ligand specificity.”
    Endocrinology 149(10) 5088–96
    Abstract PDF PubMed Link

  5. Xu, W. Sanz, A. Pardo, L. Liu-Chen, LY.
    “Activation of the mu opioid receptor involves conformational rearrangements of multiple transmembrane domains.”
    Biochemistry 47(40) 10576–86
    Abstract PDF PubMed Link

2007


  1. Pardo, L. Deupi, X. Dolker, N. Lopez-Rodriguez, ML. Campillo, M.
    “The Role of Internal Water Molecules in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors.”
    Chembiochem 8(1) 19–24
    Abstract PDF PubMed Link

  2. Smit, MJ. Vischer, HF. Bakker, RA. Jongejan, A. Timmerman, H. Pardo, L. Leurs, R.
    “Pharmacogenomic and Structural Analysis of Constitutive G Protein-Coupled Receptor Activity.”
    Annu Rev Pharmacol Toxicol 47(0) 53–87
    Abstract PDF PubMed Link

  3. Perez-Sacau, E. Diaz-Penate, RG. Estevez-Braun, A. Ravelo, AG. Garcia-Castellano, JM. Pardo, L. Campillo, M.
    “Synthesis and Pharmacophore Modeling of Naphthoquinone Derivatives with Cytotoxic Activity in Human Promyelocytic Leukemia HL-60 Cell Line.”
    J Med Chem 50(4) 696–706
    Abstract PDF PubMed Link

  4. Deupi, X. Dolker, N. Lopez-Rodriguez, M.L. Campillo, M. Ballesteros, J.A. Pardo, L.
    “Structural models of class A G protein-coupled receptors as a tool for drug design: insights on transmembrane bundle plasticity”
    Curr Top Med Chem 7(10) 991–998
    Abstract PDF PubMed Link

  5. Springael, JY. de Poorter, C. Deupi, X. Van, Durme, J. Pardo, L. Parmentier, M.
    “The activation mechanism of chemokine receptor CCR5 involves common structural changes but a different network of interhelical interactions relative to rhodopsin.”
    Cell Signal 19(7) 1446–56
    Abstract PDF PubMed Link

  6. Kobilka, BK. Deupi, X.
    “Conformational complexity of G-protein-coupled receptors.”
    Trends Pharmacol Sci 28(8) 397–406
    Abstract PDF PubMed Link

  7. Dolker, N. Deupi, X. Pardo, L. Campillo, M.
    “Charge-charge and cation-π interactions in ligand binding to G protein-coupled receptors”
    Theor Chem Account 118(3) 579–588
    Abstract PDF

  8. Reyes, CP. Munoz-Martinez, F. Torrecillas, IR. Mendoza, CR. Gamarro, F. Bazzocchi, IL. Nunez, MJ. Pardo, L. Castanys, S. Campillo, M. Jimenez, IA.
    “Biological Evaluation, Structure-Activity Relationships, and Three-Dimensional Quantitative Structure-Activity Relationship Studies of Dihydro-beta-agarofuran Sesquiterpenes as Modulators of P-Glycoprotein-Dependent Multidrug Resistance.”
    J Med Chem 50(20) 4808–4817
    Abstract PDF PubMed Link

  9. Oliver-Bonet, M. Campillo, M. Turek, PJ. Ko, E. Martin, RH.
    “Analysis of replication protein A (RPA) in human spermatogenesis.”
    Mol Hum Reprod 13(12) 837–44
    Abstract PDF PubMed Link

2006


  1. Mathiesen, JM. Christopoulos, A. Ulven, T. Royer, JF. Campillo, M. Heinemann, A. Pardo, L. Kostenis, E.
    “On the Mechanism of Interaction of Potent Surmountable and Insurmountable Antagonists with the Prostaglandin D2 Receptor CRTH2.”
    Mol Pharmacol 69(4) 1441–53
    Abstract PDF PubMed Link

  2. Codina-Pascual, M. Campillo, M. Kraus, J. Speicher, MR. Egozcue, J. Navarro, J. Benet, J.
    “Crossover frequency and synaptonemal complex length: their variability and effects on human male meiosis.”
    Mol Hum Reprod 12(2) 123–133
    Abstract PDF PubMed Link

  3. Pujol, A. Benet, J. Staessen, C. Van, Assche, E. Campillo, M. Egozcue, J. Navarro, J.
    “The importance of aneuploidy screening in reciprocal translocation carriers.”
    Reproduction 131(6) 1025–1035
    Abstract PDF PubMed Link

  4. Verzijl, D. Pardo, L. van, Dijk, M. Gruijthuijsen, YK. Jongejan, A. Timmerman, H. Nicholas, J. Schwarz, M. Murphy, PM. Leurs, R. Smit, MJ.
    “Helix 8 of the Viral Chemokine Receptor ORF74 Directs Chemokine Binding.”
    J Biol Chem 281(46) 35327–35
    Abstract PDF PubMed Link

2005


  1. Lopez-Rodriguez, ML. Morcillo, MJ. Fernandez, E. Benhamu, B. Tejada, I. Ayala, D. Viso, A. Campillo, M. Pardo, L. Delgado, M. Manzanares, J. Fuentes, JA.
    “Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. 8.(1) Computational Simulation of Ligand-Receptor Interaction of 5-HT(1A)R Agonists with Selectivity over alpha(1)-Adrenoceptors.”
    J Med Chem 48(0) 2548–2558
    Abstract PDF PubMed Link

  2. Urizar, E. Claeysen, S. Deupi, X. Govaerts, C. Costagliola, S. Vassart, G. Pardo, L.
    “An Activation Switch in the Rhodopsin Family of G Protein-coupled Receptors: THE THYROTROPIN RECEPTOR.”
    J Biol Chem 280(17) 17135–41
    Abstract PDF PubMed Link

  3. Lopez-Rodriguez, ML. Benhamu, B. de, la, Fuente, T. Sanz, A. Pardo, L. Campillo, M.
    “A Three-Dimensional Pharmacophore Model for 5-Hydroxytryptamine(6) (5-HT(6)) Receptor Antagonists.”
    J Med Chem 48(13) 4216–4219
    Abstract PDF PubMed Link

  4. Codina-Pascual, M. Oliver-Bonet, M. Navarro, J. Campillo, M. Garcia, F. Egozcue, S. Abad, C. Egozcue, J. Benet, J.
    “Synapsis and meiotic recombination analyses: MLH1 focus in the XY pair as an indicator.”
    Hum Reprod 20(8) 2133–9
    Abstract PDF PubMed Link

  5. Cortes-Selva, F. Jimenez, IA. Munoz-Martinez, F. Campillo, M. Bazzocchi, IL. Pardo, L. Ravelo, AG. Castanys, S. Gamarro, F.
    “Dihydro-beta-Agarofuran Sesquiterpenes: A New Class of Reversal Agents of the Multidrug Resistance Phenotype Mediated by P-Glycoprotein in the Protozoan Parasite Leishmania.”
    Curr Pharm Des 11(24) 3125–39
    Abstract PDF PubMed Link

  6. Jongejan, A. Bruysters, M. Ballesteros, J.A. Haaksma, E. Bakker, R.A. Pardo, L. Leurs, R.
    “Linking agonist binding to histamine H1 receptor activation.”
    Nature Chem Biol 1(2) 98–103
    Abstract PDF PubMed Link

  7. Xu, W. Campillo, M. Pardo, L. Kim, de, Riel, J. Liu-Chen, LY.
    “The Seventh Transmembrane Domains of the delta and kappa Opioid Receptors Have Different Accessibility Patterns and Interhelical Interactions.”
    Biochemistry 44(49) 16014–16025
    Abstract PDF PubMed Link

2004


  1. Vassart, G. Pardo, L. Costagliola, S.
    “A molecular dissection of the glycoprotein hormone receptors.”
    Trends Biochem Sci 29(0) 119–26
    Abstract PDF PubMed Link

  2. Carballeira, J.D. Alvarez, E. Campillo, M. Pardo, L. Sinisterra, J.V.
    “Diplogelasinospora grovesii IMI 171018, a new whole cell biocatalyst for the stereoselective reduction of ketones”
    Tetrahedron: Asymmetry 15(6) 951–962
    Abstract PDF PubMed Link

  3. Pujol, A. Benet, J. Campillo, M. Codina-Pascual, M. Egozcue, J. Navarro, J.
    “The use of a cell-cycle phase-marker may decrease the percentage of errors when using FISH in PGD.”
    Cytogenet Genome Res 105(1) 29–35
    Abstract PDF PubMed Link

  4. Cortes-Selva, F. Campillo, M. Reyes, CP. Jimenez, IA. Castanys, S. Bazzocchi, IL. Pardo, L. Gamarro, F. Ravelo, AG.
    “SAR Studies of Dihydro-beta-agarofuran Sesquiterpenes as Inhibitors of the Multidrug-Resistance Phenotype in a Leishmania tropica Line Overexpressing a P-Glycoprotein-Like Transporter.”
    J Med Chem 47(3) 576–587
    Abstract PDF PubMed Link

  5. Montanelli, L. Van, Durme, JJ. Smits, G. Bonomi, M. Rodien, P. Devor, EJ. Moffat-Wilson, K. Pardo, L. Vassart, G. Costagliola, S.
    “Modulation of ligand selectivity associated with activation of the transmembrane region of the human follitropin receptor.”
    Mol Endocrinol 18(8) 2061–73
    Abstract PDF PubMed Link

  6. Lopez-Rodriguez, M.L. Benhamu, B. Morcillo, M.J. Porras, E. Lavandera, J.L. Pardo, L.
    “Serotonin 5-HT7 Receptor Antagonists.”
    Curr. Med. Chem. – Centr. Nerv. Syst. Agents 4(3) 203–214
    Abstract PDF

  7. Deupi, X. Olivella, M. Govaerts, C. Ballesteros, JA. Campillo, M. Pardo, L.
    “Ser and Thr Residues Modulate the Conformation of Pro-Kinked Transmembrane alpha-Helices.”
    Biophys J 86(1) 105–15
    Abstract PDF PubMed Link

2003


  1. Govaerts, C. Bondue, A. Springael, JY. Olivella, M. Deupi, X. Le, Poul, E. Wodak, SJ. Parmentier, M. Pardo, L. Blanpain, C.
    “Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.”
    J Biol Chem 278(3) 1892–903
    Abstract PDF PubMed Link

  2. Smits, G. Campillo, M. Govaerts, C. Janssens, V. Richter, C. Vassart, G. Pardo, L. Costagliola, S.
    “Glycoprotein hormone receptors: determinants in leucine-rich repeats responsible for ligand specificity.”
    EMBO J 22(11) 2692–703
    Abstract PDF PubMed Link

  3. Lopez-Rodriguez, ML. Benhamu, B. Murcia, M. Alvaro, E. Campillo, M. Pardo, L.
    “Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists.”
    J Comput Aided Mol Des 17(8) 515–24
    Abstract PDF PubMed Link

  4. Lopez-Rodriguez, ML. Morcillo, MJ. Fernandez, E. Benhamu, B. Tejada, I. Ayala, D. Viso, A. Olivella, M. Pardo, L. Delgado, M. Manzanares, J. Fuentes, JA.
    “Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1, 2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.”
    Bioorg Med Chem Lett 13(8) 1429–32
    Abstract PDF PubMed Link

  5. Lopez-Rodriguez, ML. Porras, E. Morcillo, MJ. Benhamu, B. Soto, LJ. Lavandera, JL. Ramos, JA. Olivella, M. Campillo, M. Pardo, L.
    “Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.”
    J Med Chem 46(26) 5638–50
    Abstract PDF PubMed Link

  6. Bosch, D. Campillo, M. Pardo, L.
    “Binding of proteins to the minor groove of DNA: What are the structural and energetic determinants for kinking a basepair step?”
    J Comput Chem 24(6) 682–91
    Abstract PDF PubMed Link

  7. Pujol, A. Boiso, I. Benet, J. Veiga, A. Durban, M. Campillo, M. Egozcue, J. Navarro, J.
    “Analysis of nine chromosome probes in first polar bodies and metaphase II oocytes for the detection of aneuploidies.”
    Eur J Hum Genet 11(4) 325–36
    Abstract PDF PubMed Link

2002


  1. Smits, G. Govaerts, C. Nubourgh, I. Pardo, L. Vassart, G. Costagliola, S.
    “Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG.”
    Mol Endocrinol 16(4) 722–35
    Abstract PDF PubMed Link

  2. Claeysen, S. Govaerts, C. Lefort, A. Van, Sande, J. Costagliola, S. Pardo, L. Vassart, G.
    “A conserved Asn in TM7 of the thyrotropin receptor is a common requirement for activation by both mutations and its natural agonist.”
    FEBS Lett 517(1) 195–200
    Abstract PDF PubMed Link

  3. Lopez-Rodriguez, ML. Benhamu, B. Morcillo, MJ. Murcia, M. Viso, A. Campillo, M. Pardo, L.
    “5-HT(4) receptor antagonists: structure-affinity relationships and ligand-receptor interactions.”
    Curr Top Med Chem 2(6) 625–41
    Abstract PDF PubMed Link

  4. Lopez-Rodriguez, ML. Murcia, M. Benhamu, B. Viso, A. Campillo, M. Pardo, L.
    “Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.”
    J Med Chem 45(22) 4806–15
    Abstract PDF PubMed Link

  5. Olivella, M. Deupi, X. Govaerts, C. Pardo, L.
    “Influence of the Environment in the Conformation of alpha-Helices Studied by Protein Database Search and Molecular Dynamics Simulations.”
    Biophys J 82(6) 3207–13
    Abstract PDF PubMed Link

  6. Lopez-Rodriguez, ML. Vicente, B. Deupi, X. Barrondo, S. Olivella, M. Morcillo, MJ. Behamu, B. Ballesteros, JA. Salles, J. Pardo, L.
    “Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1A) receptor ligands to explore the three-dimensional structure of the receptor.”
    Mol Pharmacol 62(1) 15–21
    Abstract PDF PubMed Link

  7. Guitart, M. Jimenez, M. Giraldo, J. Gonalons, E. Badia, A.
    “Changes in electrophysiological properties in the prostatic portion of vas deferens from spontaneously hypertensive rats.”
    Naunyn Schmiedebergs Arch Pharmacol 366(5) 425–30
    Abstract PubMed Link

  8. Giraldo, J. Vivas, NM. Vila, E. Badia, A.
    “Assessing the (a)symmetry of concentration-effect curves: empirical versus mechanistic models.”
    Pharmacol Ther 95(1) 21–45
    Abstract PubMed Link

  9. Bassols, Farres, A. Bosch-Llonch, F. Campillo-Grau, M. Banos-Diez, JE.
    “[An epidemiologic study of headache and its treatment in the general population of Catalonia].”
    Rev Neurol 34(10) 901–8
    Abstract PubMed Link

2001


  1. Nebot-Cegarra, J. Fabregas, PJ. Campillo, M. Ricart, S.
    “Separation between the digestive and the respiratory lumina during the human embryonic period: morphometric study along the tracheo-oesophageal septum.”
    J Anat 198(0) 117–24
    Abstract PDF PubMed Link

  2. Lopez-Rodriguez, ML. Murcia, M. Benhamu, B. Olivella, M. Campillo, M. Pardo, L.
    “Computational model of the complex between GR113808 and the 5-HT4 receptor guided by site-directed mutagenesis and the crystal structure of rhodopsin.”
    J Comput Aided Mol Des 15(11) 1025–33
    Abstract PDF PubMed Link

  3. Govaerts, C. Blanpain, C. Deupi, X. Ballet, S. Ballesteros, JA. Wodak, SJ. Vassart, G. Pardo, L. Parmentier, M.
    “The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation.”
    J Biol Chem 276(16) 13217–25
    Abstract PDF PubMed Link

  4. Lopez-Rodriguez, ML. Murcia, M. Benhamu, B. Viso, A. Campillo, M. Pardo, L.
    “3-D-QSAR/CoMFA and recognition models of benzimidazole derivatives at the 5-HT(4) receptor.”
    Bioorg Med Chem Lett 11(21) 2807–11
    Abstract PDF PubMed Link

  5. Lopez-Rodriguez, M.L. Benhamu, B. Viso, A. Murcia, M. Pardo, L.
    “Study of the bioactive conformation of novel 5-HT4 receptor ligands: influence of an intramolecular hydrogen bond”
    Tetrahedron 57(31) 6745–6749
    Abstract PDF

  6. Govaerts, C. Lefort, A. Costagliola, S. Wodak, SJ. Ballesteros, JA. Van, Sande, J. Pardo, L. Vassart, G.
    “A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.”
    J Biol Chem 276(25) 22991–9
    Abstract PDF PubMed Link

  7. Lopez-Rodriguez, ML. Morcillo, MJ. Fernandez, E. Rosado, ML. Pardo, L. Schaper, K.
    “Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.”
    J Med Chem 44(2) 198–207
    Abstract PDF PubMed Link

  8. Bosch, D. Foloppe, N. Pastor, N. Pardo, L. Campillo, M.
    “Calibrating nucleic acids torsional energetics in force-field: insights from model compounds”
    J Mol Struct (THEOCHEM) 537(0) 283–305
    Abstract PDF

2000


  1. Pardo, L. Campillo, M. Bosch, D. Pastor, N. Weinstein, H.
    “Binding mechanisms of TATA box-binding proteins: DNA kinking is stabilized by specific hydrogen bonds.”
    Biophys J 78(4) 1988–96
    Abstract PDF PubMed Link

  2. Moron, JA. Campillo, M. Perez, V. Unzeta, M. Pardo, L.
    “Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.”
    J Med Chem 43(9) 1684–91
    Abstract PDF PubMed Link

  3. Rodriguez-Martos, A. Rubio, G. Auba, J. Santo-Domingo, J. Torralba, L. Campillo, M.
    “Readiness to change questionnaire: reliability study of its Spanish version.”
    Alcohol & Alcoholism 35(3) 270–5
    Abstract PDF PubMed Link

  4. Ballesteros, JA. Deupi, X. Olivella, M. Haaksma, EE. Pardo, L.
    “Serine and threonine residues bend alpha-helices in the chi(1) = g(-) conformation.”
    Biophys J 79(5) 2754–60
    Abstract PDF PubMed Link

1999


  1. Bassols, A. Bosch, F. Campillo, M. Canellas, M. Banos, JE.
    “An epidemiological comparison of pain complaints in the general population of Catalonia (Spain).”
    Pain 83(1) 9–16
    Abstract PDF PubMed Link

  2. Tabernero, A. Giraldo, J. Vila, E.
    “Modelling the changes due to the endothelium and hypertension in the alpha-adrenoreceptor-mediated responses of rat aorta.”
    J Auton Pharmacol 19(4) 219–28
    Abstract PubMed Link

  3. Guitart, M. Giraldo, J. Gonalons, E. Vila, E. Badia, A.
    “Adrenergic and purinergic components in bisected vas deferens from spontaneously hypertensive rats.”
    Br J Pharmacol 128(4) 873–80
    Abstract PubMed Link

  4. Giraldo, J.
    “A pH-dependent model of the activation mechanism of the histamine H2 receptor.”
    Biochem Pharmacol 58(2) 343–53
    Abstract PubMed Link

1998


  1. Pastor, N. Pardo, L. Weinstein, H.
    “How the TATA box selects its protein partner.”
    ACS Symposium Series 682(0) 329–345
    Abstract

  2. Pardo, L. Pastor, N. Weinstein, H.
    “Selective binding of the TATA box-binding protein to the TATA box-containing promoter: analysis of structural and energetic factors.”
    Biophys J 75(5) 2411–21
    Abstract PDF PubMed Link

  3. Pardo, L. Sepulcre, F. Cladera, J. Dunach, M. Labarta, A. Tejada, J. Padros, E.
    “Experimental and theoretical characterization of the high-affinity cation-binding site of the purple membrane.”
    Biophys J 75(2) 777–84
    Abstract PDF PubMed Link

  4. Pardo, L. Pastor, N. Weinstein, H.
    “Progressive DNA bending is made possible by gradual changes in the torsion angle of the glycosyl bond.”
    Biophys J 74(5) 2191–8
    Abstract PDF PubMed Link

  5. Giraldo, J.
    “The slope parameter and the receptor reserve.”
    Trends Pharmacol Sci 19(11) 445–6
    PubMed Link

  6. Giraldo, J. Wodak, SJ. van, Belle, D.
    “Conformational analysis of GpA and GpAp in aqueous solution by molecular dynamics and statistical methods.”
    J Mol Biol 283(4) 863–82
    Abstract PubMed Link

1997


  1. Jones, M. Abrahams, PH. Sanudo, JR. Campillo, M.
    “Incidence and morphology of accessory heads of flexor pollicis longus and flexor digitorum profundus (Gantzer’s muscles)”
    J Anat 191(0) 451–5
    Abstract PDF PubMed Link

  2. Pardo, L. Campillo, M. Giraldo, J.
    “The effect of the molecular mechanism of G protein-coupled receptor activation on the process of signal transduction.”
    Eur J Pharmacol 335(1) 73–87
    Abstract PDF PubMed Link

  3. Pardo, L. Weinstein, H.
    “On the structure and activity of membrane receptors: a computational simulation of ligand-triggered activation in a model 5HT1A receptor”
    Int. J. Quantum Chem. 63(0) 767–780
    PDF

  4. Pastor, N. Pardo, L. Weinstein, H.
    “Does TATA matter? A structural exploration of the selectivity determinants in its complexes with TATA box-binding protein.”
    Biophys J 73(2) 640–52
    Abstract PDF PubMed Link

  5. Vivas, NM. Giraldo, J. Tabernero, A. Vila, E. Badia, A.
    “Use of the operational model of agonism and [3H]prazosin binding to assess altered responsiveness of alpha1-adrenoceptors in the vas deferens of spontaneously hypertensive rat.”
    Naunyn Schmiedebergs Arch Pharmacol 356(3) 383–91
    Abstract PubMed Link

  6. Vila, E. Vivas, NM. Tabernero, A. Giraldo, J. Arribas, SM.
    “Alpha 1-adrenoceptor vasoconstriction in the tail artery during ageing.”
    Br J Pharmacol 121(5) 1017–23
    Abstract PubMed Link

  7. Hoyo, Y. Giraldo, J. Vila, E.
    “Effects of L-NG-nitro-arginine on noradrenaline induced contraction in the rat anococcygeus muscle.”
    Br J Pharmacol 120(6) 1035–8
    Abstract PubMed Link